Have any supplements been studied for nail fungus?

In vitro (lab-based) and animal studies have tested supplements on other types of fungal infections, but no research has tested if these supplements treat nail fungus specifically in humans. Compounds like monolaurin (which is derived from coconut oil), or certain flavonoids (e.g., liquiritigenin) may have general antifungal effects.^[1][2][3] Overall, more human evidence is needed before any supplement can be recommended for treating nail fungus.