Antioxidants have been studied for OSA, since it is associated with increased levels of oxidative stress. Although oxidative stress is reduced by CPAP therapy[1], the relationship between antioxidant levels in the body and OSA isn’t well-understood.[2]. One small cohort study noted an improvement in OSA symptoms after 8 weeks vitamin D supplementation in participants with mild OSA and low vitamin D levels at the start of the trial.[3] This particular study lacked appropriate blinding and controls to yield conclusive results, however, and studies examining associations between vitamin D levels and OSA have reported inconsistent results.[4] Nitrate supplements have also been studied for OSA, and were found in one randomized crossover trial to reduce the OSA-induced increase in early-morning blood pressure.[5]
Have any supplements been studied for obstructive sleep apnea?
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•Last Updated: May 16, 2025
Antioxidants and nitrate supplements have been studied for obstructive sleep apnea (OSA), and some evidence suggests that supplemental vitamin D may improve symptoms in certain people. However, the overall understanding of the relationship between these supplements and OSA remains inconclusive, and inconsistent results have been reported in various studies.