How could carbohydrate type affect NAFLD?

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    Last Updated: April 23, 2025

    Beverages that are high in simple sugars can significantly increase liver fat, potentially without affecting body weight, and restricting their intake may help reduce liver fat. Additionally, glycemic index may influence liver fat, and some evidence suggests that a high-glycemic index diet can increase liver fat, compared to a low-glycemic index diet.

    Relative to other carbohydrate sources, beverages rich in simple sugars (i.e., glucose, fructose, sucrose) can significantly increase liver fat,[1][2] potentially even without changes in body weight.[3][4] Moreover, restricting simple sugar intake effectively decreases liver fat.[5][6] It’s currently unclear whether restricting simple sugar intake reduces liver fat independent of changes in body weight, but there is some evidence to suggest that it might.[7][8]

    Glycemic index is another factor that may influence the effect of carbohydrates on liver fat,[9] but there is very little research on this topic. In an exploratory 7-day randomized crossover trial, a eucaloric high-glycemic index diet increased liver fat compared to a eucaloric low-glycemic index diet in healthy young men.[10]

    How could carbohydrate type affect NAFLD? - Examine