Epidemiological studies suggest that a family history of varicose veins is a risk factor for developing the condition, but the specific genes that are responsible for the disease have yet to be identified. Genome-wide association studies indicate that heritability may account for around 28% of the variance in a person’s susceptibility to varicose veins; genes that are involved in height, vascular development and integrity, blood pressure, limb development, and skeletal abnormalities are associated with the condition.[1]
How do genetics affect the risk for varicose veins?
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•Last Updated: May 16, 2025
Family history is a risk factor for varicose veins, and heritability accounts for approximately 28% of susceptibility. Although specific genes have not been identified, associations exist with genes related to height, vascular development, blood pressure, and limb development.