Berberine seems to produce most of its benefits through acting on high-level controllers of energy homeostasis, including the enzymes adenosine monophosphate-activated protein kinase (AMPK), protein kinase c (PKC), and sirtuin 1 (SIRT 1), all of which regulate biological processes related to metabolism, immunity, and inflammation.[1]
How does berberine work?
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•Last Updated: May 16, 2025
Berberine primarily exerts its effects by influencing key regulators of energy balance, such as AMPK, PKC, and SIRT 1, which are involved in metabolic, immune, and inflammatory processes.