How does beta-alanine work?

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    Last Updated: May 16, 2025

    Beta-alanine works by increasing carnosine levels in the body because it combines with L-histidine to form carnosine. This compound acts as a proton buffer and helps to maintain pH levels in cells during intense exercise by binding to hydrogen ions, thus allowing for prolonged high-intensity performance.

    Beta-alanine works by elevating levels of carnosine in the body.

    When beta-alanine is ingested, it combines with another amino acid called L-histidine, forming carnosine. Carnosine acts as an intracellular proton buffer — it protects against drops in pH (increases in acidity). Carnosine is stored in cells (i.e., brain and skeletal muscle tissue), and in response to increasing levels of acidosis, such as during intense exercise, carnosine buffers intracellular acidity by binding to hydrogen ions (H+), allowing for a longer duration of exercise at a higher intensity.