How does CBD work?

    Last Updated: May 16, 2025

    CBD operates through various receptors; it potentially reduces pain and stress via the TRPV1 receptor, alleviates stress and depression through the 5HTI-alpha receptor, and addresses inflammation via the A2A receptors. Its effectiveness appears to be enhanced when it is used in combination with THC.

    CBD works in myriad ways, which are still being explored. For instance, it may reduce pain and stress via the TRPV1 receptor,[1][2][3] stress and depression via the 5HTI-alpha receptor,[4][5] and inflammation via the A2A receptors.[6]

    Unfortunately, CBD seems to work better in combination with THC.

    How does CBD work? - Examine