DHEA is believed to work indirectly by being converted to androgens or estrogens in peripheral target cells, and might theoretically also work directly by stimulating neurotransmitter receptors in the brain.[1]
How does DHEA work?
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•Last Updated: May 16, 2025
DHEA is thought to function indirectly via conversion by the body into androgens or estrogens in peripheral target cells. It may also have a direct effect by stimulating neurotransmitter receptors in the brain.