How does glutamine work?

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    Last Updated: May 16, 2025

    Glutamine improves digestion by strengthening the intestinal barrier, reducing permeability, and promoting the growth of intestinal cells. Additionally, it serves as a fuel source for immune cells and may have anti-inflammatory effects by lowering certain inflammatory markers and aiding in the production of the antioxidant glutathione.

    Glutamine may improve digestion by strengthening the intestinal barrier by reducing intestinal permeability, aiding tight junctions, and promoting enterocyte growth (cells that line the intestines).[1]

    Glutamine is the preferred source of fuel for enterocytes as well as lymphocytes, an important cell of the immune system.[2]

    Glutamine may act as an anti-inflammatory agent by reducing interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-ɑ), and C-reactive protein levels. It may also help produce glutathione, the body’s principal antioxidant.[1][3]