As a hormone, melatonin’s main function is to promote the onset and maintenance of sleep. It achieves this by activating melatonin receptors in the brain, which inhibit neuronal activity and regulate the body’s circadian rhythm. Melatonin receptors have been identified in many other tissues as well (including the intestinal tract, pancreas, and immune cells), which may explain some of melatonin’s other health effects.
How does melatonin work?
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•Last Updated: May 16, 2025
Melatonin promotes sleep by activating receptors in the brain that inhibit neuronal activity and regulate circadian rhythms. Additionally, melatonin receptors are found in various tissues, which may contribute to its other health effects.