Phosphatidylserine (PS) affects the hypothalamus-pituitary-adrenal axis (HPA axis). The HPA axis is a hormonal signaling pathway which operates under a feedback loop. Perceived stress stimulates the hypothalamus to release corticotropin-releasing factor (CRF), which in turn stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH promotes the release of cortisol from the adrenal glands on the kidneys. Cortisol acts on multiple systems in the body in order to meet its needs in times of stress. Higher levels of cortisol decrease the production of CRF and thereby end the feedback cycle. PS may reduce ACTH and cortisol levels.[1][2]
Supplemental PS can cross the blood-brain barrier, where it supports communication between neurons[3] and affects memory, learning and language processes.[4]