S-adenosylmethionine regulates biological processes by transferring methyl groups, adenosyl groups, amino groups, and more to proteins, lipids, nucleic acids (e.g., DNA), and several other metabolites in many enzymatic reactions.[1][2][3][4]
Because several conditions — liver disease, kidney disease, heart disease, and neurodegenerative conditions, etc. — are associated with low levels of S-adenosylmethionine in blood or tissues,[1][5][6][7][8][9][10][11] supplementation might help restore normal levels. However, even if this is possible, the evidence supporting the therapeutic efficacy of supplementation with S-adenosylmethionine is weak (as described above).