Lion's mane supplements are occasionally used alongside microdosing of psychedelic therapy, specifically with psilocybin-containing “magic mushrooms”, in the hope of achieving a synergetic effect on the brain. Niacin (vitamin B3) is also sometimes added to this combination due to its vasodilation properties, which are believed to enhance the bioavailability of both lion’s mane and hallucinogenic components in magic mushrooms (psilocybin). However, there aren’t many studies available on the potential benefits of taking lion’s mane with psychedelics; the few studies that have examined this combination have not reported a significant impact on mental health beyond what is observed with psychedelics alone.[1]
In what other context is lion’s mane used?
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•Last Updated: May 16, 2025
Lion's mane supplements are sometimes used in conjunction with microdosing of psilocybin-containing mushrooms to potentially enhance brain effects, and niacin is added for its vasodilation properties. However, limited studies suggest that this combination does not significantly improve mental health outcomes beyond those achieved with psychedelics alone.