Family history has been identified as a significant risk factor for developing BPH. The risk of BPH is increased 4-fold in men who have a relative with BPH, and this risk increases to 6-fold if their brother has BPH.[1] Recent genetic studies have identified a “genetic signature” of BPH in which two genes — BMP5 and CXCL13 — seem to play a role in the pathogenesis of BPH.[2]
Is BPH a genetic condition?
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•Last Updated: May 16, 2025
Family history is a significant risk factor for developing benign prostatic hyperplasia (BPH), with a 4-fold increased risk if a relative has it and 6-fold if a brother is affected. Recent genetic studies have identified 2 genes, BMP5 and CXCL13, that may contribute to the development of BPH.