Is creatine beneficial in Parkinson’s disease?

Although a 2017 meta-analysis found that supplementation with creatine increased functional independence (as assessed with the Schwab and England Activities of Daily Living Scale), the size of the effect was very small (and potentially clinically irrelevant). Moreover, no effects of creatine were observed on mental health, motor symptoms, or activities of daily living as assessed with the Unified Parkinson's Disease Rating Scale (UPDRS).^[1]