Although a 2017 meta-analysis found that supplementation with creatine increased functional independence (as assessed with the Schwab and England Activities of Daily Living Scale), the size of the effect was very small (and potentially clinically irrelevant). Moreover, no effects of creatine were observed on mental health, motor symptoms, or activities of daily living as assessed with the Unified Parkinson's Disease Rating Scale (UPDRS).[1]
Is creatine beneficial in Parkinson’s disease?
Written by:
Fact-checked
by:
•Last Updated: May 16, 2025
A 2017 meta-analysis indicated that creatine supplementation may slightly improve functional independence in Parkinson's disease, but the effect size was small and was likely clinically irrelevant. Additionally, creatine showed no effect on mental health, motor symptoms, or daily living activities.