Is glucosamine suitable for people with a shellfish allergy?

Shellfish allergy is commonly triggered by immunoglobulin E (IgE) antibodies present in the flesh of the shellfish, rather than in the shell. Glucosamine supplements are typically derived from the shells of shellfish, which are not known to contain significant levels of IgE-triggering proteins. Some preliminary studies did not observe allergic reactions to glucosamine in individuals with shellfish allergy. However, it's essential to conduct larger, more comprehensive studies to ensure the safety of glucosamine supplements for people with shellfish allergy and to definitively rule out any potential contraindications.^[1]