Limited research in humans suggests that nattokinase is absorbed and present in the blood between 2 and 24 hours after ingestion.[1][2] However, nattokinase can be degraded by stomach acid and exposure to high temperatures (over 50 degrees Celsius (122 degrees Fahrenheit)), which could reduce its fibrinolytic effect. Nattokinase seems to be stable at pH values of 6 to 9 and temperatures of 30 to 50 degrees Celsius.[1][3] To improve its stability in the stomach, nattokinase is often formulated with various protective ingredients. Formulations of nattokinase to protect it from being denatured by gastric acid include encapsulation (coatings) and nanoemulsion (dispersing and coating submicron particles). Inactive ingredients used to coat or immobilize the enzyme include chitosan, mesoporous silica, polyglutamic acid peptide, hydroxypropyl cellulose, polylactic-co-glycolic acid, and others.[4][3]
Is nattokinase well-absorbed?
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•Last Updated: October 30, 2024