Should people with SLE take vitamin D?

Maybe. Vitamin D is an important supplement to consider in the context of SLE. Many people with SLE suffer from photosensitivity and consequently get little to no sun exposure. This increases their risk for vitamin D deficiency, which is associated with increased disease severity.^[1] Some studies find that vitamin D supplementation reduces fatigue in SLE patients^[2], while others find no difference in SLE disease activity.^[3] However, given the risks associated with vitamin D deficiency, people with SLE should talk to their medical provider about checking their vitamin D levels and supplementing if appropriate.