Maybe. Vitamin D is an important supplement to consider in the context of SLE. Many people with SLE suffer from photosensitivity and consequently get little to no sun exposure. This increases their risk for vitamin D deficiency, which is associated with increased disease severity.[1] Some studies find that vitamin D supplementation reduces fatigue in SLE patients[2], while others find no difference in SLE disease activity.[3] However, given the risks associated with vitamin D deficiency, people with SLE should talk to their medical provider about checking their vitamin D levels and supplementing if appropriate.
Should people with SLE take vitamin D?
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•Last Updated: May 16, 2025
People with systemic lupus erythematosus (SLE) may benefit from supplemental vitamin D due to their increased risk of deficiency from limited sun exposure, which can worsen disease severity. People with SLE should consult their healthcare provider about checking their vitamin D levels and considering supplementation if necessary.