Limited human evidence suggests that agmatine may have mild to moderate side effects like diarrhea and mild nausea, but these resolve with time or treatment secession.[1][2] Further research is needed to determine whether agmatine is safe to use.
What are agmatine’s main drawbacks?
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•Last Updated: May 16, 2025
Agmatine may cause mild to moderate side effects such as diarrhea and mild nausea, which typically resolve over time or with discontinuation of use. More research is necessary to establish its safety for use in humans.