Cell culture (in vitro) experiments show that extracts from Anacyclus pyrethrum have antimicrobial and antioxidant activity.[1][2] Several animal studies have confirmed the antioxidant activity,[3][4] along with anti-inflammatory[5][3][4] and immunomodulatory effects.[6][7][8] Animal studies also show that extracts from Anacyclus pyrethrum can act as a painkiller,[5][9][3] have neuroprotective effects against seizures in models of epilepsy,[10][11][12][13] and enhance memory.[13][14] Further studies in male rats also find evidence of a benefit to sperm health (count, viability, and motility[15][16]) and libido.[17][18]
Unfortunately, these effects have only been demonstrated in cell culture or animal experiments; no clinical data exist. Therefore, it is not currently possible to make conclusions about the potential efficacy of Akarkara supplements on human health. The only human data currently available is from a study of 13 women in whom a 12-week treatment with a face cream containing Anacyclus pyrethrum extracts showed potential to protect skin from damage.[19]