Though there are few human clinical trials studying the effects of apigenin as a single compound, at least in part because of its instability when isolated, preclinical studies have suggested that apigenin may improve outcomes in anxiety,[1] brain function,[2][1][3][4] oxidative stress,[5][6][7] inflammation,[8][9][10][11][12][13][14] and hormonal regulation (testosterone,[15] estrogen,[16] and cortisol[17][18]).
What are apigenin’s main benefits?
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•Last Updated: May 16, 2025
Apigenin may improve outcomes related to anxiety, brain function, oxidative stress, inflammation, and hormonal regulation, including levels of testosterone, estrogen, and cortisol, according to preclinical studies. However, there are few human clinical trials on apigenin due to its instability when isolated.