There is little evidence to suggest that apigenin causes adverse effects when consumed as part of a normal diet.[1] No toxicity has been reported as a result of dietary apigenin intake.[2][3] It should be noted, however, that when dosages exceed typical intake to an extreme (30–100 mg/kg of body weight), sedation has been reported as a side effect.[4]
What are apigenin’s main drawbacks?
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•Last Updated: May 16, 2025
Apigenin is generally considered safe, and there is little evidence of adverse effects when consumed as part of a normal diet, and no toxicity has been reported. However, extremely high doses (30–100 mg per kg of body weight) may lead to sedation as a side effect.