There is limited evidence that citrulline supplementation can reduce ratings of perceived exertion, decrease muscle soreness, and increase power output and total repetitions performed in resistance training.[1][2][3] More research is needed to determine whether different supplement dosages, different formulations, or longer periods of ingestion can further improve exercise performance.
A considerable amount of research suggests that supplementation with citrulline mildly reduces blood pressure.[4] More research is needed on citrulline’s potential effects for erectile dysfunction, but a small amount of research suggests a beneficial effect.[5]