Although the safety of long-term supplementation with high doses of citrulline warrants further investigation, research to date suggests that it is well tolerated in most individuals. Unlike arginine and ornithine, high doses of citrulline don't seem to result in gastrointestinal distress.[1]
What are citrulline’s main drawbacks?
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•Last Updated: May 16, 2025
Citrulline is generally well tolerated in most people, and high doses do not appear to cause gastrointestinal distress, unlike arginine and ornithine. However, the safety of long-term supplementation with high doses of citrulline requires further investigation.