It’s important to note that rodent studies show that daily supplementation with D-aspartic acid does not cause toxicity.[1] Furthermore, human studies have not reported evidence of toxicity or serious side effects.[2][3][4] One resistance training study of 20 men with no health conditions did report irritability, nervousness, rapid heart rate, and headache in 2 participants receiving D-aspartic acid, but the same adverse effects were also reported by 1 participant in the placebo group.[4] In the absence of toxicity or serious side effects, the main drawback of supplementation with D-aspartic acid is the lack of evidence for a beneficial effect in humans.
What are D-aspartic acid’s main drawbacks?
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•Last Updated: May 16, 2025
Supplementation with D-aspartic acid has not been shown to cause toxicity or serious side effects in humans, although some participants in a resistance training study reported mild adverse effects. The main drawback of D-aspartic acid is the lack of evidence supporting its beneficial effects in humans.