Studies have not yet reported any side effects associated with hesperidin supplementation. However, it’s important to note that the absence of side effects in research does not definitively rule them out, and further investigation is warranted. One study found that a 500 mg dose of hesperidin methyl chalcone (HMC) did not affect renal and hepatic function markers.[1]
One meta-analysis found that hesperidin supplementation was linked to an increase in body weight, which could potentially be concerning for people with obesity or overweight. However, this effect has not been consistently observed in other studies, and it may be influenced by many factors beyond hesperidin supplementation.[2]