What are inositol’s main drawbacks?

Although studies examining the safety of intravenously-administered inositol in preterm infants do not find a greater incidence of adverse events compared to placebo,^[1][2][3] a thorough dose-response study of orally-administered inositol assessing safety and side effects is currently lacking. Consequently, the side effects of inositol are not clearly defined. However, while many randomized controlled trials of inositol fail to report side effects,^[4] meta-analyses typically conclude that side effects following supplementation with inositol are not common.^{[4][5][6][7][8]} That said, gastrointestinal problems like nausea and diarrhea have been documented at very high orally-administered doses (e.g., up to 12 grams of inositol per day) in adults.^[9][10]