According to one systematic review and meta-analysis, negative outcomes were not reported when evaluating the outcomes of the IE approach.[1]
It’s important to note that IE is not suitable for people affected by anorexia nervosa who are following a mechanical eating (or structured eating) approach as part of their treatment for weight restoration. This is because their hunger and fullness cues are often altered due to disordered eating. In this case, a more structured eating schedule may be more appropriate.[2]