Nausea and constipation may occur after kratom ingestion, especially if taken in higher amounts and/or more frequently.[1] High doses of kratom might also trigger rare serious adverse events such as hallucinations, tremor, seizure, coma, and respiratory depression. The active alkaloid in kratom (mitragynine) has been found in a number of postmortem analyses, in addition to other substances (e.g., fentanyl, heroin, benzodiazepines). Because of the presence of these other substances, it is unknown whether and how kratom contributed to the cause of death. Finally, chronic kratom use can lead to dependence and precipitate an opioid-like withdrawal, including symptoms of agitation, nausea, and vomiting.[2]
What are kratom’s main drawbacks
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•Last Updated: May 16, 2025
Kratom can cause nausea and constipation, particularly at higher doses, and may lead to serious adverse effects like hallucinations and seizures. Additionally, chronic use can result in dependence and withdrawal symptoms similar to those of opioids.