In typical dosages, melatonin appears fairly safe. Side effects are both uncommon and usually mild, including daytime sleepiness, headache, and nausea. Very rarely, serious adverse effects resulting from melatonin supplementation (often in very high doses) have been reported. Melatonin is not addictive.
What are melatonin’s main drawbacks?
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•Last Updated: May 16, 2025
Melatonin is generally safe at typical dosages; uncommon and usually mild side effects include daytime sleepiness, headache, and nausea. Serious adverse effects are rare and are typically associated with very high doses; melatonin is not addictive.