MSM is on the FDA’s list of generally recognized as safe (GRAS) substances.[1] However, there is very limited safety data, with most research to date being done on animals. Minor adverse events, such as gastrointestinal upset, skin rash, and allergies have been reported. In one animal study, these adverse effects were first noted at around 17 times the maximum recommended dosage. No changes to kidney or liver function have been noted with MSM use up to 6 grams per day.[2][3][4] In a study done on rats, MSM was found to be safe during pregnancy, but this is not yet confirmed in human studies,[5] and while the use of MSM during breast feeding is thought to be safe, there is little evidence to support this.[6]
What are MSM’s main drawbacks?
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•Last Updated: October 30, 2024