What are NMN’s main benefits?

    Written by:
    Bill Willis, Nick Milazzo

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    by:

    Marina Shkayeva, Natalka Roshak
    Last Updated: May 16, 2025

    Nicotinamide mononucleotide (NMN) is a supplement that may increase NAD+ levels, and preliminary research suggests benefits such as improved physical ability in aging populations and better cardiovascular biomarkers. However, more extensive trials are necessary to confirm these effects in humans.

    NMN is taken as a supplement to increase levels of the coenzyme NAD+. It is unknown whether NMN will have the same therapeutic effects in humans as seen in rodent models, but emerging evidence is promising.[1][2]

    So far, most randomized controlled trials in humans have focused on proving the safety of NMN supplements and their ability to increase blood NAD+ levels in different populations. Some clinical research has shown that NMN increases physical ability in aging populations,[3] improves cardiovascular disease biomarkers such as arterial stiffness,[4] and increases cellular NAD+/NADH levels.[1] Although these results have been promising, additional large-scale trials are needed to better understand the benefits in humans.