Overall, the results of randomized controlled trials of phosphatidylserine (PS) have been inconsistent. Trials examining PS for cognition in adults over age 50 have somewhat consistently showed benefits at dosages of 100–300 mg per day for 2–6 months, although more research is needed to clarify these benefits.[1][2][3][4] PS supplementation also might reduce perceived stress levels in people with high chronic stress, though studies of PS for stress have serious limitations and have shown mixed results.[5][6][7] PS has also been studied in the context of physical activity, though studies have shown even less consistent results here.[8][9][10][11][12]
What are phosphatidylserine’s main benefits?
Written by:
Fact-checked
by:
•Last Updated: May 16, 2025
Phosphatidylserine (PS) may provide cognitive benefits for adults older than age 50 at dosages of 100 to 300 mg per day, although research results are inconsistent and further studies are needed. Additionally, supplemental PS might help reduce perceived stress in people with high chronic stress, but evidence for this is also mixed and limited.