In short-to-moderate intake durations (months to a year) and in moderate doses, rhodiola is safe, with little to no side effects. Although reports of adverse effects are rare, dizziness, dry mouth, and headache were noted in a small number of participants in some trials.[1][2] Rhodiola has been shown to interact with liver enzymes in vitro, indicating a possibility for drug interactions. It increased the concentration and decreased clearance of a particular antihypertensive drug in rabbits,[3] confirming interaction with at least one class of drugs in vivo.
What are Rhodiola rosea's main drawbacks?
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•Last Updated: May 16, 2025
Rhodiola rosea is generally safe with few side effects, though some people may experience dizziness, dry mouth, or headaches. Additionally, it has the potential to interact with liver enzymes, which could lead to drug interactions, as evidenced by its effects on an antihypertensive drug in animal studies.