There are no medical treatments that target CFS directly; they focus exclusively on managing symptoms. Not all symptoms have good treatment options (e.g., postexertional malaise), but there are medications for sleep issues (e.g., trazodone, benzodiazepines, antihistamines like Benadryl), cognitive issues (e.g., stimulants), and pain (e.g., nonsteroidal anti-inflammatory drugs, muscle relaxants, cannabis).[1]
What are some of the main medical treatments for chronic fatigue syndrome?
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•Last Updated: May 16, 2025
There are no direct medical treatments for chronic fatigue syndrome; instead, treatments focus on managing symptoms. Options include medications for sleep issues, cognitive problems, and pain, although not all symptoms have effective treatments.