Usually, DOMS does not require medical treatment. With rest and/or lowering the intensity of exercise, symptoms should subside within 5–7 days. Acetaminophen or oral and/or topical nonsteroidal anti-inflammatory drugs may decrease soreness; however, prolonged use of these medications is not recommended.[1][2]
What are some of the main medical treatments for DOMS?
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•Last Updated: May 16, 2025
Delayed onset muscle soreness typically does not require medical treatment because symptoms usually resolve with rest or reduced exercise intensity within 5 to 7 days. Although acetaminophen and nonsteroidal anti-inflammatory drugs may help alleviate soreness, long-term use of these medications is not advised.