Medications for diarrhea-predominant IBS include antidiarrheals that reduce intestinal motility (organized contractions of the digestive tract) and reduce water content in the bowel. Doctors may also prescribe antibiotics to treat underlying infections or small intestinal bacterial overgrowth (SIBO). Drugs for constipation include over-the-counter laxatives or prescriptions that increase water content in the bowel or enhance intestinal motility. Antidepressants or antispasmodics can be used to normalize intestinal motility.[1]
What are some of the main medical treatments for IBS?
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•Last Updated: May 16, 2025
Medical treatments for irritable bowel syndrome (IBS) vary based on symptoms; antidiarrheals and antibiotics are used for diarrhea-predominant IBS, and laxatives and motility-enhancing drugs are prescribed for constipation. Additionally, antidepressants and antispasmodics may help normalize intestinal motility.