Over-the-counter pain relievers such as ibuprofen, naproxen, or acetaminophen may help ease mild PMS symptoms (e.g., cramps, headaches, breast tenderness). When symptoms of PMS are severe, selective serotonin reuptake inhibitors (SSRIs) such as paroxetine (Paxil), fluoxetine (Prozac), citalopram (Celexa), or sertraline (Zoloft) can be tried. Oral contraceptives have also shown some benefit for reducing PMS symptoms. Theoretically, these work by regulating fluctuations of estrogen and progesterone throughout a cycle.[1]
What are some of the main medical treatments for PMS?
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•Last Updated: May 16, 2025
The main medical treatments for premenstrual syndrome include over-the-counter pain relievers like ibuprofen and acetaminophen for mild symptoms, and severe symptoms may be treated with selective serotonin reuptake inhibitors (SSRIs) and oral contraceptives, which help regulate hormonal fluctuations.