There are no standard treatments for POTS. Rather, treatment is focused on decreasing heart rate, increasing blood volume, and/or stabilizing blood pressure. Some of the most commonly prescribed drugs include mineralocorticoids (e.g., fludrocortisone) vasopressin receptor agonists (e.g., desmopressin), beta-blockers (e.g., metoprolol and propranolol), and alpha-agonists (e.g., midodrine). One liter of normal saline given intravenously over an hour also seems to be helpful, but this therapy isn’t recommended for long-term use. [1]
What are some of the main medical treatments for postural orthostatic tachycardia syndrome?
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•Last Updated: May 16, 2025
There are no standard treatments for postural orthostatic tachycardia syndrome, but management focuses on reducing heart rate, increasing blood volume, and stabilizing blood pressure. Common medications include mineralocorticoids, vasopressin receptor agonists, beta-blockers, and alpha-agonists, along with occasional intravenous saline, though the latter is not recommended for long-term use.