SIBO is conventionally treated with certain classes of antibiotics that are poorly absorbed — unlike systemic antibiotics, which easily enter circulation — so they act primarily in the intestines. This leads to fewer side effects and lower chances of antimicrobial resistance, which leads to potentially deadly microbes becoming unaffected by antibiotics.[1] SIBO is generally considered to be cured (often referred to as being eradicated or decontaminated) based on normal breath test results.[2][3]
Fecal microbiota transplants (FMT) aren’t an established treatment yet, but there is promising preliminary research. [4]