In vitro and animal studies observed additional benefits associated with lion’s mane supplementation; although clinical research has not yet confirmed these findings.
In a study using topically wounded rats and lion's mane water extract, it was observed that the accumulation of immune cells in the wound was reduced in the lion's mane group compared to the control.[1]
Additionally, lion’s mane fruiting body extract was found to reduce triglyceride levels in hyperlipidemic rats and increase the expression of several genes involved in fat metabolism, thus mitigating weight gain during a high-fat diet.[2] On the other hand, the mycelium of lion’s mane appeared to have cholesterol-reducing properties.[3]
Finally, one in vitro study showed that lion’s mane extract displayed antioxidant activity, likely due to its phenolic component. It also exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria, with specificity for certain bacteria depending on the extraction solvent used. Furthermore, the ethanolic extract showed dose-dependent cytotoxic activity against lung adenocarcinoma cells.[4]