In one open-label, non-randomized, phase-2 study, researchers investigated the effects of maitake supplementation on myelodysplastic syndromes (MDS). MDS is a group of conditions characterized by bone marrow failure and an impaired development of myeloid cells, which can progress to acute myeloid leukemia (AML). The study’s results indicated that while neutrophil and monocyte counts did not significantly increase, after 12 weeks there was an observed rise (ex vivo) in the mean endogenous neutrophil reactive oxygen species (ROS) production, which are essential for bactericidal activity.[1]
Furthermore, in one randomized clinical trial, maitake D-fraction supplementation in individuals with advanced laryngeal and pharyngeal cancer was found to reduce the side effects induced by concurrent chemo-radiotherapy (CCRT) and increase the participants’ overall quality of life. Additionally, it expedited the recovery of physical functions and relieved symptoms such as pain, dry mouth, sticky saliva, speech, and general discomfort six months post-treatment.[2]