There is minimal research on the use of ecdysteroids in humans, so the dosing remains unclear. While no clear severe side effects have been demonstrated, the safety of these products is also uncertain. A study done in young men without known health conditions found that dosages up to 800 mg daily did not cause any notable damage to the liver or kidneys over a 10-week period.[1] No adverse effects have been noted in studies done on other mammals, with doses up to 100 mg per kg of body weight producing no noted adverse effects in rabbits.[2] Studies on other mammals do not always apply to humans, and more evidence is needed to confirm the safe dose for humans.
Another problem is that commercially available ecdysteroid products are not regulated. This means they may not contain what they claim to contain, or they may not contain the amount of the active substance stated on the label.[3][4]