What are the main signs and symptoms of hypothyroidism?

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    Last Updated: May 16, 2025

    Hypothyroidism can lead to a range of signs and symptoms, and the main ones include fatigue, cold intolerance, weight gain, depression, slowed heart rate, dry skin, brittle hair, and constipation.

    Lack of thyroid hormone can result in various signs and symptoms including the following:[1]

    • Fatigue and weakness
    • Intolerance of cold temperature
    • Decreased sweating
    • Weight gain
    • Depression
    • Slowed heart rate
    • Constipation
    • Slowed movement, speech, and thinking
    • Dry skin, brittle hair
    • Swelling in the face and other body parts
    • Goiter (enlarged thyroid)
    • Joint and muscle pain
    • Irregular menstrual periods and infertility in women