Crying is the main sign of colic, but flushing of the face, clenched fists, drawing up of the legs, and flatulence can also occur.[1] These signs of colic are more likely to occur in the late afternoon and evening hours of the day.[2]
There are typically few, if any, quantifiable signs of colic, though fecal calprotectin can occasionally be higher in infants with colic.[3][4][5][6]