Most people with NAFLD do not present with symptoms, and the disease remains silent until it has progressed to an advanced stage. In the early stages, fatigue and upper abdominal pain may be reported. Elevated levels of serum alanine aminotransferase and aspartate aminotransferase are also typically observed. In cases of very severe NAFLD, jaundice (i.e., yellowing of the eyes and skin), edema, ascites (i.e., excess fluid trapped in the abdomen), and/or confusion may be present.
What are the main signs and symptoms of NAFLD?
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•Last Updated: May 16, 2025
Most people with nonalcoholic fatty liver disease (NAFLD) are asymptomatic until the disease reaches an advanced stage, though early symptoms may include fatigue and upper abdominal pain. In severe cases, symptoms can escalate to jaundice, edema, ascites, and confusion, along with elevated liver enzyme levels.