Glucosyl-hesperidin (G-Hesperidin) is a synthetically modified form of hesperidin with three (instead of two) glycoside groups. This modification greatly enhances its water solubility and bioavailability compared to regular hesperidin.[1] Once ingested, G-hesperidin is converted to hesperidin, which is then converted into hesperetin in the colon.
Another synthetic variant of hesperidin is hesperidin-7,3'-O-dimethylether (HDME). This variant is more lipid-soluble and has higher phosphodiesterase inhibitory potential than hesperetin.[2]