The underlying cause of Alzheimer’s is not known for certain, but several explanations have been proposed. The most common theory is that Alzheimer’s disease is the result of neurodegeneration and a buildup of misfolded proteins called amyloid plaques and tau tangles, which are almost always found in the brains of people with the disease. However, this “amyloid hypothesis” has been criticized. Regardless of the cause of Alzheimer’s disease, various modifiable and nonmodifiable factors, including aging, depression, diabetes, and genetics, have been linked to a higher risk of the disease.
What causes Alzheimer’s disease?
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•Last Updated: May 16, 2025
The exact cause of Alzheimer’s disease is uncertain, but it is commonly associated with neurodegeneration and the accumulation of amyloid plaques and tau tangles in the brain. Additionally, various factors such as aging, depression, diabetes, and genetics are associated with an increased risk of developing the disease.