The precise causes of BPH are not well understood, but several factors — both modifiable and nonmodifiable — have been implicated, including hormones (i.e., dht, estrogen), genetics, dietary factors, inflammation, and oxidative stress.[1] According to some evidence, the risk of BPH is increased by four-fold in people with a first-degree relative with BPH.[2] Also, metabolic-syndrome is consistently associated with an increased risk of BPH,[3] so it may be involved in the development and progression of the condition.
What causes BPH?
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•Last Updated: May 16, 2025
The exact causes of benign prostatic hyperplasia (BPH) are not fully understood, but factors such as hormones, genetics, dietary influences, inflammation, oxidative stress, and metabolic syndrome have been associated with its development. Additionally, having a first-degree relative with BPH can increase the risk by 4 times.