What causes BPH?

The precise causes of BPH are not well understood, but several factors — both modifiable and nonmodifiable — have been implicated, including hormones (i.e., dht, estrogen), genetics, dietary factors, inflammation, and oxidative stress.^[1] According to some evidence, the risk of BPH is increased by four-fold in people with a first-degree relative with BPH.^[2] Also, metabolic-syndrome is consistently associated with an increased risk of BPH,^[3] so it may be involved in the development and progression of the condition.