Diabetes, heart disease, and hypertension are the three most common diseases that lead to CKD. Some medications when used in excess or for prolonged periods (like chemotherapies and nonsteroidal anti-inflammatories) can cause CKD as well. Other causes of kidney damage that can lead to and/or worsen CKD include systemic infections, trauma or injury to the kidneys, congenital abnormalities, and autoimmune conditions.[1]